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KMID : 1143420230160100271
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Public Health Weekly Report
2023 Volume.16 No. 10 p.271 ~ p.289
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Long-Term Prognosis of Chronic Kidney Disease Patients in the Republic of Korea: From the KNOW-CKD Study
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Kang Eun-Jeong
Oh Kook-Hwan
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Abstract
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The aim of this study was to investigate the incidences of renal events, all-cause deaths, and cardiovascular events from Korean chronic kidney disease (CKD) patients. This study was conducted using the data obtained from the ‘KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD),’ a long-term prospective cohort study of CKD in the Republic of Korea (ROK). From January 2011 to June 2016, adult non-dialyzed CKD patients aged 20?75 were enrolled at nine hospitals in the ROK. During follow-up until March 31, 2022, the glomerular filtration rate declined at a rate of 2.62±0.07 ml/min/1.73 m2/year on the average. During the follow-up, 183 deaths (11.7 per 1,000 person-years), 221 cardiovascular events (15.2 per 1,000 person-years), and 689 dialysis or transplantation events (53.1 per 1,000 person-years) occurred. All-cause mortality and incidence of cardiovascular disease (CVD) were the highest in the diabetic nephropathy group, and tended to increase at higher CKD stages. Compared to the general population, CKD patients exhibited higher risk of adverse outcomes; the hazard ratio (HR) for all-cause mortality was 2.25 (95% confidence interval [CI] 1.95?2.60), and the HR for cardiovascular events was 1.42 (95% CI 1.00?2.02). All-cause mortality risk In CKD patients in all CKD stages significantly increased compared to that in the general population. In a meta-analysis and international comparison study, Korean CKD patients exhibited relatively higher risk of renal events, while they demonstrated relatively lower all-cause mortality and CVD risk. These results provide an important implication in establishing national policies and treatment plan for Korean CKD patients.
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KEYWORD
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Chronic kidney disease, Mortality, Cardiovascular disease
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